COMPARATIVE ANALYSIS OF HUMAN AND LIVESTOCK АСЕ2 RECEPTORS FOR SARS-COV-2
Angiotensin-converting enzyme 2 (ACE2) is a receptor for SARS-CoV-2 spike protein on the cell surface and plays a key role in the development of COVID-19. The high conservatism of ACE2 structure in different species and the large number of human contacts with livestock increase the risk of spreading SARS-CoV-2 among the ones if the virus will be able to penetrate and replicate in the cells of such animals successfully. The result of this course of events may be the emergence of the animal reservoirs of coronavirus disease.
To assess this possibility, a comparative analysis of the amino acid sequences of ACE2 receptors for SARS-CoV-2 in different species of livestock with human ACE2 was performed. High degrees of identity and similarity were found for ACE2 receptors of donkey, horse, rabbit, alpaca, lama, dromedary, pig, sheep, goat and cattle (taurine and zebu), lower – for poultry species (chicken, duck and turkey). The data obtained in this study are consistent with the results of previous experiments on the ability of SARS-CoV-2 to interact with ACE2 receptors of different animal species. Although there is evidence of pig, chicken and duck resistance to SARS-CoV-2 by intranasal inoculation, the risk of the virus adaptation to livestock infecting, given the mutational variability of the virus, remains high, which makes relevant the further studies of SARS-CoV-2 interactions with livestock.
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